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KMID : 1134820110400050673
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Journal of the Korean Society of Food Science and Nutrition
2011 Volume.40 No. 5 p.673 ~ p.681
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Effects of Eriobotrya japonica Lindl. (Loquat) Leaf Ethanol Extract on Cholesterol and Antioxidative Activity in Rats Fed a High-Fat/High-Cholesterol Diet
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Kim Ah-Ra
Hwang Yun-Gyeong
Lee Jae-Joon
Jung Hae-Ok
Lee Myong-Ryeol
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Abstract
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We investigated the effects of an ethanol extract of Eriobotrya japonica Lindl. (loquat) leaves (EJ) on the lipid metabolism of serum, liver, and adipose tissue, and antioxidative activity in rats fed a fat/cholesterol diet for four weeks. Male Sprague-Dawley rats weighing 207 g were divided into 4 groups: a normal diet group (N), a high-fat/high-cholesterol diet group (HFC), a high-fat/high-cholesterol diet group administered 200 ㎎/㎏ day EJ (HFC-EJL), and a high-fat/high-cholesterol diet group administered 400 ㎎/㎏/day EJ (HFC-EJH). The serum ALT and AST activities of the EJ groups were lower than those of HFC group, but there was no significant change in serum ALP or LDH activities. The serum total and LDL-cholesterol, atherogenic index, and cardiac risk factor tended to be decreased in the EJ groups compared to the HFC group, while the serum HDL-cholesterol decreased in the HFC group and increased only minimally in the EJ groups. The total cholesterol in liver and mesenteric adipose tissues was lower in the EJ groups than in the HFC group. Triglycerides in the mesenteric and epididymal adipose tissues were lower in the EJ groups than in the HFC group. The liver GSH levels of the EJ groups were significantly lower than the HFC group. The liver TBARS content was significantly lower in the EJ groups than in the HFC group. These results suggest that EJ ethanol extract may improve the lipid metabolism of serum, liver, and adipose tissue and prevent oxidative stress by stimulating antioxidative systems in rats fed a high-fat/high-cholesterol diet.
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KEYWORD
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Eriobotrya japonica Lindl., high fat/high cholesterol diet, cholesterol, antioxidative activities
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